Dinas et. al 2018

Field(s): Obesity & Exercise


Citation: Dinas, P. C., Nintou, E., Psychou, D., Granzotto, M., Rossato, M., Vettor, R., . . . Flouris, A. D. (2018). Association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: A cross-sectional study. F1000Res, 7, 327. doi:10.12688/f1000research.14198.2





 Dinas 2018 Association of fat mass profile wit title



Background: Atrial natriuretic peptide increases lipolysis in human adipocytes by binding to natriuretic peptide receptor-A (NPRA). The aim of the current study was to examine the associations of NPRA mRNA of subcutaneous adipose tissue with fat mass, fat-free mass, body mass index (BMI) and arterial blood pressure in medication-free healthy men. Method: Thirty-two volunteers [age (years): 36.06+/-7.36, BMI: 27.60+/-4.63 (kg/m (2))] underwent assessments of body height/weight, % fat mass, fat-free mass (kg), blood pressure, and a subcutaneous adipose tissue biopsy via a surgical technique. Results: We found that NPRA mRNA was negatively associated with % fat mass (r=-0.40, R (2)=0.16, p=0.03) and BMI (r=-0.45, R (2)=0.20, p=0.01). Cohen's f (2) effect size analyses showed a small effect size between NPRA mRNA and BMI ( f (2) =0.25). One-way analysis of variance with Bonferroni post-hoc tests showed a tendency for mean differences of NPRA mRNA across BMI categories (p=0.06). This was confirmed by Cohen's d effect size analyses revealing a large effect size of NPRA mRNA between obese individuals (BMI>/=30 kg/m (2)) and either normal weight (BMI=19-25 kg/m (2); d=0.94) or overweight (BMI=25-30 kg/m (2); d=1.12) individuals. Conclusions: NPRA mRNA is negatively associated with % fat mass and BMI in medication-free healthy men, suggesting a possible role of NPRA in the control of fat mass accumulation.